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Journal of Environmental Toxicology 2005;20(4):303-309.
한국인 본태성 고혈압 환자군에서 ACE2 유전자에 존재하는 A1075G 다형성의 분포에 관한 연구
장민희, 강병용, 이재구, 이강오
The Distribution of Genetic Polymorphism in the ACE2 Gene in Korean Essential Hypertensives
Min Hee Jang , Byung Yong Kang , Jae Koo Lee , Kang Oh Lee
Essential hypertension has been considered as multifactorial disease resulted from the interaction of both environmental and genetic factors. The renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure homeostasis. Recently, a homologue of angiotensin I converting enzyme, ACE2 has been focused on as a candidate gene of essential hypertension in the experiments using animal model and human being. In this study, we carried out an association study in order to clarify the relationship between the A1075G polymorphism in the ACE2 gene and essential hypertension in Korean subjects. Because this polymorphism is located on human chromosome X, the statistical analysis for each gender was performed separately. There were no significant differences in allele distribution of the A1075G polymorphism in the ACE2 gene between normotensives and hypertensives in the both gender groups, respectively. However, this polymorphism was significantly associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) values in only female groups (P<0.05). Thus, these results may suggest the probable role of ACE2 gene in the inter-individual susceptibility of female group to blood pressure variability.
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