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Journal of Environmental Toxicology 2005;20(3):249-258.
한국인 본태성 고혈압군에서 에스트로젠 수용체-α 유전자에 존재하는 다형성의 분포에 관한 연구
김지영, 강병용, 이강오
The Distributions of Three Genetic Polymorphisms in the Estrogen Receptor-α Gene in Korean Essential Hypertensives
Ji Young Kim , Byung Yong Kang , Kang Oh Lee
ABSTRACT
Blood pressure, obesity and bone mineral density are multifactorial traits influenced by genetic factor. The purpose of this study was to clarify the association between three genetic polymorphisms in the estrogen receptor-α (ER-α) gene and essential hypertension in korean population. One hundred and seventy-one people including 90 normotensives and 81 essential hypertensives were recruited. Among genetic polymorphisms studied, the Xba I RFLP in the intron 1 of this gene polymorphism was significantly associated with essential hypertension in women, suggesting the sexual dimorphism in genetic effect (P<0.05). Further studies suggest that a larger sample size of this study are needed.
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