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Environ Anal Health Toxicol > Volume 39:2024 > Article
Environmental Analysis Health and Toxicology 2024;39(3):e2024023-0. doi: https://doi.org/10.5620/eaht.2024023
Effect of fluoride-induced testicular alteration in rats fed a high-fat diet
Manuel Sánchez-Gutiérrez , Itziar Hernández-Martínez , Eduardo Osiris Madrigal-Santillán , Kevin Francisco Flores-Elizalde , Jeannett Alejandra Izquierdo-Vega
Toxicology Laboratory, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda de la Concepcion, Tilcuautla, 42160, Hidalgo, Mexico
Corresponding Author: Jeannett Alejandra Izquierdo-Vega ,Email: ivega@uaeh.edu.mx
Received: November 4, 2023;  Accepted: January 25, 2024.
Previous research on the well-known environmental pollutant fluoride has demonstrated that fluoride exposure can lead to oxidative stress-related male infertility. Obesity is another public health issue that has a detrimental impact on male fertility. Previously, findings on fluoride toxicity in high-fat diet (HFD) conditions associated with oxidative stress have been evidenced. This study aimed to evaluate the impact of subchronic fluoride exposure (5 mg/kg) plus a HFD on testicular alteration in Wistar rats. Animals were divided into four groups (control, HFD, fluoride, and fluoride 5 mg/kg plus HFD). The HFD contained a 50% kcal increase in fat (saturated fat), after 90 days of co-exposure to fluoride plus HFD, the animals showed a significant decrease in the adiposity index. The co-exposed group showed oxidative damage assessed through decreased glutathione (GSH) concentration (p < 0.0001), increased concentrations of malondialdehyde (MDA) (p < 0.0001), and the oxidation of proteins (p < 0.0001) vs the control group. Finally, testicular histology exhibited a reduction in spermatogonia and spermatocytes. The results of the study indicate that under these conditions, subchronic co-exposure to fluoride under HFD conditions could protect against the accumulation of epididymal fat, however, oxidative alteration at the testicular level is maintained.
Keywords: fluoride, obesity, oxidative stress, oxidative damage, testes
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