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Environ Anal Health Toxicol > Volume 38:2023 > Article
Environmental Analysis Health and Toxicology 2023;38(4):e2023025-0. doi: https://doi.org/10.5620/eaht.2023025
Ethanol extract of aloe vera ameliorates Artemether-Lumefantrine-induced reproductive toxicity in adult male Albino rats (Wistar Strain)
Mustapha Olamide Oluwayemisi1 , Fatola Olanrewaju2 , Ola-Davies Olufunke3 , Ajayi Olusola Lawrence4 , Oyeyemi Matthew1
1Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
2Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
3Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
4Department of Veterinary Pathology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
Corresponding Author: Mustapha Olamide Oluwayemisi ,Email: midemusti@gmail.com
Received: January 26, 2023;  Accepted: October 27, 2023.
Artemether-Lumefantrine (AL) is one of the alternative drugs used in treating malaria – an endemic scourge in Africa. AL has been reported to generate free radicals with long term use implicated in testicular pathologies. The antioxidative properties of Aloe vera (AV) has been well documented. This study investigated the ameliorative effect of ethanol extract of Aloe Vera on Artemether-Lumefantrine induced testicular toxicity. Thirty adult male albino rats were randomly divided into 5 groups (Control, AL-dosed, AV-dosed, AL+AV concurrently administered and AV-pretreated). Spermiogram, serum testosterone, testicular histopathology and inducible nitric oxide synthase (iNOS) immunohistochemistry were carried out. AL-dosed rats had poor spermiogram indices which were greatly improved in AV-dosed and AV-pretreated rats. These also corresponded with the testicular histopathology observations and were further buttressed by oxidative stress marker (iNOS) as AL-dosed rats had higher signal intensity compared to the control and AV-pretreated rats. Authors posit that concurrent administration of AV and AL protected testicular architecture while pretreating with AV prior AL administration improved the spermiogram. AL induces testicular pathology, thus should be used with care in male subjects. AV can confer a level of protection against these defects if used prior to administration of the drug.
Keywords: Aloe vera, Artemether-Lumefantrine, Testes, Immunohistochemistry, Spermiogram, Oxidative stress
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