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Environ Anal Health Toxicol > Volume 37:2022 > Article
Environmental Analysis Health and Toxicology 2022;37(4):e2022036-0. doi: https://doi.org/10.5620/eaht.2022036
Tissues toxicity attenuation by vitamin E on oxidative damage induced by diazinon
Kavoos Tahmasebi1, Mahvash Jafari2 , Javad Heydari1, Alireza Asgari3, Maryam Salehi4, Saeed Khazaie1, Mohammad Saleh Abedini5
1Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
4Neurosciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
5Students Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Corresponding Author: Mahvash Jafari ,Email: m.jafari145@gmail.com
Received: April 25, 2022;  Accepted: November 1, 2022.
Organophosphorus insecticides such as diazinon (DZN) are used worldwide in industry, veterinary practice, and agriculture. They may induce oxidative stress in different tissues. The use of antioxidants can protect tissues against oxidative stress. The aim of this study was to investigate the prophylactic and therapeutic roles of vitamin E against DZN–induced oxidative damage and biochemical alterations in various tissues of male Wistar rats. Thirty rats were divided into five groups: Control group received only corn oil as DZN solvent, DZN group received 100 mg/kg of DZN, E group received 150 mg/kg of vitamin E, E-DZN group received vitamin E and then dosed with DZN and DZN-E group received DZN and then dosed with vitamin E. All injections were carried out intraperitoneally. Plasma and various tissues were prepared and evaluated. Results showed that acute administration of DZN caused a significant induction of oxidative damage in the tested tissues via increased malondialdehyde level and some plasma biochemical indices, depletion of glutathione (GSH), reduced cholinesterase activity and change in the activities of superoxide dismutase, catalase and glutathione-S transferase. Treatment of rats with vitamin E resulted in an elevation in the level of GSH, normalizing the antioxidant enzymes activities and decreasing lipid peroxidation, although all these tests did not return to the normal level in certain tissues. The findings of this study suggest that both prophylactic and therapeutic treatments of rats with vitamin E provide a protective role against DZN-induced oxidative stress and cholinergic hyperactivity through free radicals scavenging and membrane stabilizing.
Keywords: diazinon, vitamin E, oxidative stress, biochemical parameters, rat, tissues
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