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Environ Anal Health Toxicol > Volume 37:2022 > Article
Environmental Analysis Health and Toxicology 2022;37(2):e2022010-0. doi: https://doi.org/10.5620/eaht.2022010
Repeated-dose 28-day dermal toxicity study of TiO2 catalyst (GST) in Sprague-Dawley rats
Jun Ho Kim1 , Myeong kyu Park1 , Jae Min Im1 , Heung Sik Seo1 , Hee Ju Park2 , Sung Soon Nah3
1Healthcare Advanced Chemical Research Institute, Korea Testing and Research Institute (KTR), 12-63, Sandan-gil, Hwasun-eup, Hwasun-gun, Jeollanam-do, 58141, Republic of Korea
2Research Laboratory, Bentech Frontier Co. Ltd., Nanosandan-ro, Nam-myeon, Jangseong, Jeollanam-do, 57248, Republic of Korea
3Division of Environment & Health, Korea Testing & Research Institute, 98, Gyoyukwon-ro, Gwacheon-si, Gyeonggi-do, 13810, Republic of Korea
Corresponding Author: Sung Soon Nah ,Email: nahs@ktr.or.kr
Received: December 1, 2021;  Accepted: April 15, 2022.
ABSTRACT
TiO2 have been studied on inhalation and skin exposure due to the properties of the materials’ use (cosmetics, paints and other products) and the additional safety information on other intake routes for the potential risk assessment is limited. The aim of this study was to obtain dose-range for subchronic study (repeated 90-day dermal toxicity) new TiO2 powder, GST produced through sludge recycling of the sewage treatment plant through repeated-dose toxicity in Sprague-Dawley (SD) rats. Three test groups for the GST were administered at 500, 1000, 2000 mg/kg B.W/day in addition to a control group (distilled water for injection). 5 male and 5 female rats were included in each group, and we examined the clinical signs, body weights, food consumption, necropsy (organ weights, macroscopic findings), hematological / biochemical parameters and histopathological findings (eye, skin). As a result of observations, there were no treatment-related effects including clinical signs, mortality, necropsy findings etc. Therefore, the present results suggest that the TiO2-related effects were not observed for dermal during 28-day and dose selection for repeated 90-day study was considered to be 500, 1000 and 2000 mg/kg B.W/day under the present study conditions.
Keywords: TiO2, repeated-dose toxicity, NOAEL, GST
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