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Environ Anal Health Toxicol > Volume 36:2021 > Article
Environmental Analysis Health and Toxicology 2021;36(3):e2021022-0. doi: https://doi.org/10.5620/eaht.2021022
Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST)
Sang Ho Kim1 , Myeong kyu Park1 , Ja Kyung Seol1 , Jae Min Im1 , Hae Sung Park1 , Heung Sik Seo1 , Hee Ju Park2 , Sung Soon Nah3
1Healthcare Research Institute, Korea Testing and Research Institute (KTR), 12-63, Sandan-gil, Hwasun-eup, Hwasun-gun, Jeollanam-do, 58141, Republic of Korea
2Research Laboratory, Bentech Frontier Co. Ltd., Nanosandan-ro, Nam-myeon, Jangseong, Jeollanam-do, 57248, Republic of Korea
3Division of Environment & Health, Korea Testing & Research Institute, 98, Gyoyukwon-ro, Gwacheon-si, Gyeonggi-do, 13810, Republic of Korea
Corresponding Author: Sung Soon Nah ,Email: nahs@ktr.or.kr
Received: November 16, 2020;  Accepted: September 10, 2021.
ABSTRACT
TiO2 NPs photocatalyst is widely used in a variety of applications and products in the environmental and energy fields, including self-cleaning surfaces, air and water purification systems, sterilization, hydrogen evolution, and photoelectrochemical conversion. The possible biological and safety effects of TiO2 dermal exposure and absorption have not been well studied and more investigations on the potential health hazards of the TiO2 are needed. This study aimed to investigate potential effect of local lesions (eye and skin irritation/corrosion) for new TiO2 material powder, GST produced through sludge recycling of the sewage treatment plant in according to the OECD test guideline (TG 404, 405) and imaging evaluation (micro-computed tomography analysis), histopathology examination. Also, P-25, commercial photocatalyst was used to compare with GST. For the eye or skin irritation/corrosion test, the test substances (GST, P-25) showed no irritation/corrosion for local lesions and the GHS category was identified as a “No hazard class”. The imaging analysis indicated that GST did not penetrate or distribute in the local lesions (eye, skin) and the treatment-related effect was not observed in histopathology. Therefore, the present study revealed that new TiO2 powder, GST was considered to be no potential effects (irritation/corrosion), penetration or distribution in the local lesions (eye, skin).
Keywords: Skin, Eye, Irritation, Corrosion, TiO2, GST
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