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Journal of Environmental Toxicology 2010;25(3):215-222.
은나노 입자의 입경 크기 및 형태에 따른 체내 동태 및 염증 반응
김수남, 노진규, 강민성, 한영아, 이병석, 김영훈, 박광식, 최경희, 박은정
1한국화학연구원 안전성평가연구소 정읍분소 흡입독성시험연구센터
2광운대학교 화학공학과
3한국화학연구원 안전성평가연구소 정읍분소 흡입독성시험연구센터
4한국화학연구원 안전성평가연구소 정읍분소 흡입독성시험연구센터
5한국화학연구원 안전성평가연구소 대전본소 독성병리부
6광운대학교 화학공학과
7동덕여자대학교 예방약학교실
8국립환경과학원 환경건강연구부
9국립환경과학원 환경건강연구부
Comparison of Distribution and Inflammatory Response by Diameter and Shape of Silver Nanoparticles
Soo Nam Kim , Jinkyu Roh , Min Sung Kang , Young-Ah Han , Byoung-Seok Lee , Younghun Kim , Kwangsik Park , Kyunghee Choi , Eun-Jung Park
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ABSTRACT
  The market size of engineered nanoparticles is rapidly increasing due to the fast application of nanotechnolo-gies into different industries and consumer products. The development of new technology and materials has improved human"s quality of life, but it also entails the possibility of exposure to new materials. In this study, we compared the distribution in the body by the inflow of silver nanoparticles having another diameter and shape at 1 h or 24 h after injection via the tail vein. And, we compared the cell composition and cytokine concentration in SAL fluid, and histopathological changes. As results, discharge of silver nanoparticles having small diameter and sphere shape was more rapid than that of big diameter or plate shape. It is estimated that the toxicity in liver and lung was proportional to accumulation level. The persistence of inflammation was also longer in mice treated with plate shape. Consequently, we suggest that the first choice of silver nanoparticles having small diameter and sphere shape in applying is desirable.
Keywords: Silver nanoparticles; Distribution; Inflammation; Cytokine; Toxicity
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