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Journal of Environmental Toxicology 2009;24(4):351-357.
Hairless 마우스에서 대추 열수추출물의 피부내 염증 및 장벽 손상 완화 효과
최소영, 김영철
계명대학교 대학원 공중보건학과
Alleviative Effects of Jujube Water Extract on the Inflammation and Barrier Damage in Hairless Mice Skin
So-Young Choi , Young-Chul Kim
ABSTRACT
  To investigate the alleviative effects of jujube water extract (JWE) on the inflammation and skin barrier damage, both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) were applied to the back skin of experimental animals for 4 weeks. And at the same time experimental materials were applied topically. Six weeks female SKH-1 hairless mice were divided into five groups (five animals for each group) including normal (N; saline), control (C; UVB+Sq-OOH+saline), vehicle control (VC; UVB+Sq-OOH+vehicle), positive control (PC; UVB+Sq-OOH+0.01% retinoic acid) and experimental (E; UVB+Sq-OOH+JWE) groups. The skin erythema index in the E group was significantly low compared to the C group (p<0.05). Lipid (p<0.05) and water (p<0.01) capacities in the E group were significantly high compared to the C group. In comparison with the C group, E group showed a relatively well preserved lipid lamellae in the epidermis and a relatively much less infiltration of mast cells in the dermis or hypodermis. As for the both absolute and relative weights of the spleen, PC group were significantly higher than the other groups. These results suggest that JWE have a considerably inhibitory effect on the inflammation and the skin barrier damage induced by UVB irradiation and Sq-OOH application.
Keywords: Jujube water extract; hairless mice; skin barrier; inflammation; lipid lamella
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