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Journal of Environmental Toxicology 2008;23(2):119-127.
육안적 관찰을 중심으로
최의숙, 권미화, 김영철
Inhibition Effects of Frankincense Oil on Skin Aging (Ⅰ) : Focussed on Gross Examination
Woi-Sook Choi , Mi-Hwa Kwon , Young-Chul Kim
  The purpose of this study was to investigate the effects of frankincense oil in a skin aging animal model. Skin aging was induced by both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the back of experimental animals for 4 weeks, And at the same time experimental materials were applied topically. Six to seven weeks female SHR-1 hairless mice were divided into five groups including nor-mal (N: saline), control (C: UVB+Sq-OOH+saline), vehicle control (VC: UVB+Sq-OOH+jojoba oil), positive control (PC: UVB+Sq-OOH+0.01% retinoic acid) and experimental (E: UVB+Sq-OOH+3% Frankincense oil) groups, five animals each group. The skin erythema index for the PC and E groups were lower than that of the C group. Whereas, both the lipid and water capacities for the PC and E groups were higher than those of the C group. Wrinkles for the C group were formed as a pattern of deep furrows and thick crests. Whereas, wrinkles for the PC and E groups were formed as a pattern of shallow furrows and thin crests which were similar to that of the N group. As for the both absolute and relative weight of the spleen, the PC group were significantly higher than the other groups. In conclusion, frankincense oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.
Keywords: frankincense oil; hairless mice; skin aging; wrinkles; lipid capacity
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