Six week-old ICR mice were divided into four groups including NC, RC, RR and RS, then they were injected with sun ginseng (RS), red ginseng (RR) and saline (RC) intraperitoneally as an amount of 60 ㎎/㎏ body weight at 1 hour, 12 hours and 36 hours before the whole body irradiation with 6.5 Gy of X-ray. And the mice were sacrificed at nine days after the irradiation. The RS group were significant increase in the weight of spleen (p＜0.05) and the numbers of endogenous spleen colony (p＜0.001) and WBC (p＜0.05) especially neutrophils, lymphocytes and monocytes in comparison with the RC group. The RR group were significant increase in the numbers of endogenous spleen colony (p＜0.01) and WBC (p＜0.05) especially neutrophils, lymphocytes and eosinophils in comparison with the RC group. The RS group exhibited a more increase in the weight of spleen and the number of endogenous spleen colony than the RR group. The values of ALT (alanine transaminase) and AST (aspartate transaminase) were significantly elevated (p＜0.05) by radiation and they were significantly decreased (p＜0.05) in the RS group to the values of the NC group. The value of TBARS(thiobarbituric acid reactive substance) was significantly elevated (p＜0.01) by radiation and it was significantly decreased (p＜0.05) in the RS group. And the values of SOD (superoxide dismutase) and CAT (catalase) were significantly increased (p＜0.05) in the RS group in comparison with the RC group. Taken together the above results, sun ginseng demonstrated the protective effects on hepatocytes and immune and hematopoietic cells in mice exposed to medium dose of irradiation, and those radioprotective effects were a little higher or similar to the red ginseng.
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