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Journal of Environmental Toxicology 2007;22(1):57-64.
배양 레이디히 세포를 이용한 은나노 물질의 산화적 스트레스발생 연구
박은정, 박광식
Induction of Oxidative Stress by Silver Nanoparticles in Cultured Leydig Cells
Eun-Jung Park , Kwangsik Park
  Nanomaterials have been used to create unique devices at the nanoscale level. However, the toxicities of nanomaterials have not been fully tested and the risk of nanomaterials has been raised as an emerging issue in these days. In this study, the cytotoxicity of silver nanoparticles was tested using cultured mouse leydig cells. As results, silver nanoparticles showed cytotoxicity with the generation of reactive oxygen species (ROS). With the increased level of ROS, intracellular glutathione level was decreased. DNA fragmentation and caspase-3 activation suggested the apoptotic mechanism of cell death in leydig cells treated with silver nanoparticles.
Keywords: silver particles; leydig cells; cytotoxicity; oxidative stress
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