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Journal of Environmental Toxicology 2006;21(4):375-380.
내분비장애물질에 대한 노출과 DNA-adduct 생성
양미희
DNA-adducts and Exposure to Endocrine Disrupting Chemicals
Mi-Hee Yang
ABSTRACT
  Endocrine disrupting chemicals (EDC) have been emphasized due to their threats in human health. Waste incinerator emission has been emphasized as a source of EDC including polychlorinateddibenzofurans (PCDD/F) and other carcinogenic polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP) has been used as an exposure biomarker for the PAHs. On the other hand, etheno-DNA adducts, e.g. 1, N<SUP>6</SUP>-ethenodeoxyadenosine (εdA), has been developed as an useful effective or response biomarker for carcinogenesis. Thus, I investigated association between urinary 1-OHP and εdA levels due to distance from an incinerator which was built more 10 years ago in the middle of a farm in P city. I designated the EDC-high and -low exposed group due to distance from the incinerator, i.e. within 2.5 ㎞ and 5.0~7.5 ㎞ from the incinerator, respectively. The study subjects were age and sex-matched males and females (mean age, 61.3±9.6 yrs; total 40 persons, male, 10; female, 10 for the each group). Urinary 1-OHP and εdA were analyzed with HPLC-FD and IP-HPLC-FD, respectively. As results, the distance from the incinerator was not associated with urinary 1-OHP nor εdA levels (p=0.43 and 0.82, respectively). On the other hand, urinary εdA levels were significantly higher in the hyperlipidemia group (N=10) than normal group (N=30). In conclusion, urinary 1-OHP nor εdA levels can not be suggested as an incinerator-related exposure nor effective biomarker. However, not only distance from the incinerator bot also systemic approaches including wind and soil contamination are required to assume exposure levels of incinerator-related EDC.
Keywords: 1-OHP; Endocrine disrupting chemicals; incinerator; DNA-adduct
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