Toxicological Study on Nonylphenol using the Soil Nematode, Caenorhabditis elegans

, Ji-Yeon Roh; , Jinhee Choi

Published online January 1, 1986

Journal of Environmental Toxicology 2006;21(4):323-330.

토양선충 Caenorhabditis elegans를 이용한 Nonylphenol의 독성 영향 연구

노지연, 최진희

Toxicological Study on Nonylphenol using the Soil Nematode, Caenorhabditis elegans

Ji-Yeon Roh , Jinhee Choi

ABSTRACT

The aim of current study was to evaluate the toxicity of nonylphenol (NP) on soil nematode, Caenorhabditi elegans.The stress-related gene expression, growth, reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations (LC<SUB>50s</SUB>) of NP was 0.15 ㎎/L. The expressions of vitellogenin-6, vitellogenin-2, cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth, reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.

Keywords: Caenorhabditis elegans; nonylphenol; stress-related gene expressions; growth; reproduction; development