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Journal of Environmental Toxicology 2006;21(3):239-244.
Caenorhabditis elegans를 이용한 phenol류의 독성 연구
정강식, 현선희, 정세영
Toxicity of Phenols to the Nematode Caenorhabditis elegans
Kang Sik Jung , Sun Hee Hyun , Se Young Choung
  Caenorhabditis elegans (C. elegans) is a free-living soil nematode that commonly used as a biological model and recently, much work has been done using C. elegans as a toxicity model. To evaluate the acute toxicity of phenols to C. elegans, worms were subsequently exposed to nine different xenobiotics. This study described lethal toxicity, reproductive toxicity and movement inhibition using 2-propylphenol, 4-propylphenol, 2-tertbutylphenol, 3-tert-butylphenol, 4-tert-butylphenol, 2-phenylphenol, 4-phenylphenol, nonylphenol and 4-dodecylphenol to C. elegans for 24 hr or 72 hr. We found that phenols used in this study were very toxic to C. elegans. The order of lethal toxicity, reproductive toxicity and movement inhibition is as follows.
Keywords: Caenorhabditis elegans; phenols; lethal toxicity; reproductive toxicity
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