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Journal of Environmental Toxicology 2006;21(2):153-163.
혈중 납 농도와 역학적 요인 및 체내 철 수준과의 관련성
박상우, 김기영, 김동원, 최성진, 김현숙, 최병선, 최미경, 박정덕
The Relation between Blood Lead Concentration, Epidemiologic Factors and Body Iron Status
Sang-Woo Park , Ki-Young Kim , Dong-Won Kim , Seong-Jin Choi , Hyun-Sook Kim , Byung-Sun Choi , Mi-Kyeong Choi , Jung-Duck Park
  Essential metals have been known to interact with non-essential toxic metals in the aspects of absorption, transport and deposition in the body. Iron deficiency has been reported to increase lead and/or cadmium absorption. The relation between iron and lead has been understood well in children but not in adults. Two hundred seventy adults (118 males and 152 females) were recruited from 3 different residental areas (rural, coastal and urban) to investigate the effects of environmental lead exposure on body iron status. The subjects were interviewed for life-style and diet of the last 24 hours, and measured for blood lead and body iron. The lead concentration in the whole blood was determined by a flameless method using an atomic absorption spectrophotometry. The body iron was evaluated with values of hemoglobin, hematocrit, RBCs, serum total iron, unsaturated iron binding capacity, total iron binding capacity and ferritin. The mean concentration of blood lead in adult was 3.31 ㎍/dL. The concentration was higher in male (3.97 ㎍/dL) than in female (2.86 ㎍/dL). The blood lead was influenced by residental area, life-style, smoking and drinking, occupation and diet habit of subjects, but not by age. A positive correlation was observed between the blood lead level and the serum iron or ferritin. These results suggest that environmental lead exposure in Korean adult may not be higher than other developed and developing countries. It is further indicated that blood lead in adult could be influenced by life-style, and environmental and genetic factors but no inverse relation with body iron as shown in children.
Keywords: body iron; blood lead; life-style; diet habit; genetic factor
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