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Journal of Environmental Toxicology 2006;21(1):87-92.
흰쥐의 사염화탄소로 유도된 간손상에 미치는 9-Amino-1, 2, 3, 4-tetrahydroacridine의 영향
신혜순, 조은정
Effect of 9-Amino-1, 2, 3, 4-tetrahydroacridine on CCl₄-Induced Liver Injury in Rats
Hea Soon Shin , Eun Jung Cho
ABSTRACT
  This study was done to investigate the protective effect of novel 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives on the hepatoprotective effect intoxicated rats induced by carbon tetrachloride (CCl₄). A series of currently derivatives of 9-amino-1, 2, 3, 4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion for the treatment of the Alzheimer’s disease. The activities of aminotransferase (aspartate and alanine) and contents of alkaline phosphatase, triglyceride and glutathione S-transferase in 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives pretreated rats were significantly decreased compared to the only carbon tetrachloride treated rats but the contents of cholesterol were increased compared to the only CCl₄ treated rats. The result indicated that 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives showed hepatoprotective effect in CCl₄ treated rats.
Keywords: hepatoprotective effect; 9-amino-1,2,3,4-tetrahydroacridine derivatives
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