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Journal of Environmental Toxicology 2005;20(3):237-242.
디메틸니트로자민에 의한 흰쥐의 간독성에 미치는 유기황화합물의 효과
신혜순, 강주연
Effect of Organic Sulfur-Containing Compounds on Hepatotoxicity in Rats Induced by N, N-Dimethylnitrosamine
Hea Soon Shin , Joo Yeon Kang
ABSTRACT
This study is focused on the hepatopreventive effect in cirrhotic rats induced by N, N-dimethylnitrosamine treatment when organic sulfur-containing compounds were orally injected. Biochemical parameters (aspatate transaminase (AST), alanine transaminase (ALT) alkaline phosphatase (ALP), t-protein and t-bilirubin) were measured in serum injured liver tissue. The increased AST and ALT values were significantly reduced by organic sulfur-containing compounds at the oral doses of 50 mg/kg. The result of morphological changes have illustrated the accumulation of liver damages, such as inflammatory cell accumulation and cirrhosis, caused by N, N-dimethylnitrosamine. Also, it was found that liver damages were prevented by the treatment of organic sulfur-containing compounds.
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