This study is focused on the hepatopreventive effect in cirrhotic rats induced by N, N-dimethylnitrosamine treatment when organic sulfur-containing compounds were orally injected. Biochemical parameters (aspatate transaminase (AST), alanine transaminase (ALT) alkaline phosphatase (ALP), t-protein and t-bilirubin) were measured in serum injured liver tissue. The increased AST and ALT values were significantly reduced by organic sulfur-containing compounds at the oral doses of 50 mg/kg. The result of morphological changes have illustrated the accumulation of liver damages, such as inflammatory cell accumulation and cirrhosis, caused by N, N-dimethylnitrosamine. Also, it was found that liver damages were prevented by the treatment of organic sulfur-containing compounds.
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