| Home | E-Submission | Sitemap | Contact Us |  
top_img
Journal of Environmental Toxicology 2005;20(3):209-213.
CYP1A1 유전자발현과 소아천식의 상관
양미희
Association between CYP1A1 Expression and Childhood Asthma
Mihi Yang
ABSTRACT
Due to steady increase of childhood asthma, exposures to air toxics including PAHs have been thought as an etiology for the asthma. PAHs-involvement in airway inflammation, such as IgE production, is the potential mechanism of the PAHs-induced asthma. Cytochrome P450s (CYPs), particularly, CYP1A1 is a known enzyme to metabolize PAHs and to be induced by PAHs. The CYP1A1 expression has been emphasized as an biomarker for PAHs-exposure. The present study was performed to clarify the etiology of childhood asthma with PAHs-exposure using mRNA expression of CYP1A1. The study subjects were Korean children who were asthma patients (cases) or other hospital controls (N = 20; age, 3~16; boys, 56%). As results, we detected expression of the CYP1A1 in all peripheral blood specimens which were collected from the subjects. Moreover, we found approx. 300 fold-higher expression of the CYP1A1 in the cases than that in the controls (p<0.01). When we considered age which was related to asthma, the above significant trend was somewhat diluted, however, the relation between asthma and the CYP1A1 expression was stronger than that between asthma and age (chi square, 7.99 vs. 3.34). Therefore, our study supports that PAHs induce or worse childhood asthma and suggests application of expression of the CYP1A1 as an initiation or progress biomarker for PAHs-induced childhood asthma.
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Share:      
METRICS
2,312
View
6
Download
Bisphenol A Exposure and Childhood Obesity  2009 December;24(4)
Association between Blood Mercury Concentration and Factor of Health/Life  2006 September;21(3)
Editorial Office
Division of Environmental Science and Ecological Engineering, Korea University
145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Tel : +82-32-560-7520   E-mail: envitoxic@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2024 by The Korean Society of Environmental Health and Toxicology & Korea Society for Environmental Analysis.     Developed in M2PI