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Journal of Environmental Toxicology 2003;18(4):271-276.
알킬페놀 화합물의 HeLa cell (HL-60)의 세포독성에 대한 QSAR연구
김명길, 김재현
QSAR Study for Cytotoxicity of Alkylphenols on HeLa Cell
Kim Myung-Gill , Kim Jae-Hyoun
ABSTRACT
The purpose of the present study was to perform experiments of cytotoxicity using HeLa cell and to evaluate the possibility that QSAR is applicable 10 the cytotoxicity of alkylphenols. Higher toxicities were found in four alkylphenols in the following order: 4-n -Nonylphenol >4-tert-Octylphenol > 4-n-Octylphenol > 4-n-Heptylphenol. Whereas other alkylphenols were apparently less toxic. By using Percent Hydrophilic Surface Area (PHSA) quantitative structure-activity relationships (QSARs) models were developed: Cytotoxicity (%) = 90.14089-4.72224 PHSA (R²=0.2046, α=0.0265). It is concluded that some of the obtained data are useful to determine whether QSAR methods can be of general use in predicting that until further work is undertaken to develop QSARs for a much wider range of homologous series of alkylphenol compounds.
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