| Home | E-Submission | Sitemap | Contact Us |  
Journal of Environmental Toxicology 2003;18(2):137-143.
합성화학물질들의 유전독성평가(Ⅷ)-마우스의 골수세포를 이용한 8종 합성화학물질들의 생체내 소핵시험
류재천, 김경란, 김연정
Evaluation of the Genetic Toxicity of Synthetic Chemicals(Ⅷ)-In vivo Bone Marrow Micronucleus Assay of 8 Synthetic Chemicals in Mice
Jae-Chun Ryu , Kyung-Ran Kim , Youn-Jung Kim
To validate and to estimate the chemical hazard play a very important role to environment and human health. The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, the clastogenicily of 8 synthetic chemicals was evaluated with bone marrow micronucleus assay in mice. The positive control, mitomycin C (2mg/kg, i.p.) revealed significant induction ratio of percentage of micronucleated polychromatic erythrocytes/1,000 polychromatic erythrocytes compared to carboxymethylcellulose control. The chemicals with relatively high LD_(50) value such as phenylisocyanate(CAS No. 103-71-9), m-aminochlorobenzene(CAS No. 108-42-9) and 2-chloro-4-nitroaniline(CAS No. 121-87-9) revealed no significant inducion of micronucleated polychromatic erythrocytes in mice. From this results. 8 synthetic chemicals widely used in industry have revealed no significant micronucleus induction of clastogenicity in mice in this experiment.
Editorial Office
Division of Environmental Science and Ecological Engineering, Korea University
145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Tel : +82-32-560-7520   E-mail: envitoxic@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2024 by The Korean Society of Environmental Health and Toxicology & Korea Society for Environmental Analysis.     Developed in M2PI