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Journal of Environmental Toxicology 2003;18(2):121-129.
합성화학물질들의 유전독성평가(Ⅶ)-합성 제초제인 Pendimethalin
류재천, 김경란
Evaluation of the Genetic Toxicity of Synthetic Chemicals(Ⅶ)-A Synthetic Selective Herbicide, Pendimethalin
Jae-Chun Ryu , Kyuug-Rau Kim
The genotoxicity of pendimethalin [N-(1-ethylpropyl)-2, 6-dinitro-3, 4-xylidine, C_(13)H_(19)N₃O₄, M.W.=281.3, CAS No. 40487-42-1], one of selective herbicide, was evaluated in bacterial gene mutation system, chromosome aberration in mammalian cell system and in vivo micronucleus assay with rodent. In bacterial gene mutation assay, pendimethalin revealed dose-dependent mutagenic potential in 313-5,000μg/plate of Salmonella typhimurium TA 98 and TA 1537 both in the absence and presence of S-9 metabolic activation system, and TA 100 only in the absence of S-9 mixture. In the TA 1535, slight increase of revertant was also observed in the presence of S-9 metabolic activation system. No mutagenic potential was observed in the TA 1535 without metabolic activation system and TA 100 in the presence of S-9 mixture. In mammalian cell system using Chinese hamster lung (CHL) fibroblast, no clastogenicity of pendimethalin was observed both in the absence and presence of S-9 metabolic activation system in the concentration range of 2.32~9.28μg/ml. And also, in vivo bone marrow micronucleus assay, pendimethalin revealed no clastogenic potential in the dose range of 203~810mg/kg body weight after oral administration in mice. Consequently, in vitro chromosome aberration with mammalian cells and in vivo bone marrow micronucleus assay revealed no clastogenic potential of pendimethalin. However, pendimethalin revealed mutagenic potential in bacterial gene mutation assay.
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