| Home | E-Submission | Sitemap | Contact Us |  
top_img
Korean Journal of Environmental Toxicology 2002;17(2):161-174.
흰쥐에서 사염화 탄소로 유도된 간독성에 미치는 더위지기 추출물의 영향- I.사염화탄소 독성유발 심화 수준에 대한 더위지기 추출물의 회복효과
Effects of an Extract from A. gmelini Weber on Hepatotoxicity Induced by CCl₄ in Rats-I. Effects of an Extract from A. gmelini on Hepatotoxicity Induced by Different Levels of CCl₄
ABSTRACT
To investigate effects of A. gmelini on the 14-day CCl₄ induced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 5,000 mg/kg b.w. to administer orally once daily. Each concentration (5:5, 2.5:7.5, 1:9, CCl₄:olive oil v/v) of CCl₄ was orally administered with 2.5 ml/kg b.w., During the experiment, halves of the rats were sacrificed every 7 day and hemanalysis was done. On the 7th day, hemanalysis showed following recovery values; AST 52.6~61.4%, ALT 55.9~86.1%, ALP 46.0~70.9%, BUN 75.7~100.0<%, TBIL 55.2~96.1%, TCHO 38.0~63.7%, and TG 55.2~96.1%. On the 14th day, recovery values of each treatment were GOT 37.7~43.1%, GPT 19.8~45.9%, ALP 58.1~95.9%, BUN 57.6~100.0<%, TBIL 78.6~100.0<%, TCHO 56.9~100.0<%, and TG 10.0~51.2%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered by administration of A. gmelini extract.
Editorial Office
Division of Environmental Science and Ecological Engineering, Korea University
145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
Tel : +82-32-560-7520   E-mail: envitoxic@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2022 by The Korean Society of Environmental Health and Toxicology & Korea Society for Environmental Analysis.     Developed in M2PI