This study involves a relationship between butyltins concentrations and histopathological changes of the digestive gland in the equilateral venus, Gomphina veneriformis exposed to TBTCl of 0.4, 0.6 and 0.8 ㎍/L for 36 weeks. In the sediment, total butyltin (∑BT) concentration was detected ND~7.54 (0.4 ㎍/L), ND~9.76 (0.6 ㎍/L), 1.22~13.13 ㎍/L (0.8 ㎍/L), respectively. Especially, TBT level in 0.8 ㎍/L group was the highest for 36 weeks. In the soft tissue, total butyltin (∑BT) concentration of the exposure group was 10.14~12.75 (control), 479.29~1,286.56 (0.4 μg/L), 563.32~2,154.82 (0.6 ㎍/L) and 1,317.70~2,132.60 ㎍/L (0.8 ㎍/L), respectively. Ratio of TBT to ∑BT of the tissue of 0.8 ㎍/L kept the lowest level for 36 weeks. The ∑BT concentrations of sediment were correlated with ∑BT concentrations in the tissue. In the exposure groups, necrosis and atrophy of columnar epithelial cell and collapse of epithelial layer in the digestive tubule. And there was a reduction in stain affinity of basophilic cell. Such histological degenerations was more severe in digestive tubule of 0.8 ㎍/L group.