Effect of Genotoxicity or Carcinogenecity Chemicals on the ROS Production

, Seo Youn Go; , Yhun Yhong Sheen

Published online January 1, 1986

Journal of Environmental Toxicology 2008;23(1):23-32.

유전독성, 발암성 화학물질이 ROS 생성에 미치는 영향

고서연, 신윤용

Effect of Genotoxicity or Carcinogenecity Chemicals on the ROS Production

Seo Youn Go , Yhun Yhong Sheen

ABSTRACT

In the present study, ROS detection of L5178Y cells that were treated with twenty test compounds in order to find out hydrogen peroxide (H₂O₂) induction for genotoxicity and carcinogenic toxicity. Twenty test compounds were consist of four classes, such as genotoxic carcinogens, genotoxic noncarcinogens, nongenotoxic carcinogens, and nongenotoxic noncarcinogens. Genotoxic carcinogens are 1,2-dibromoethane, glycidol, melphalan, diethylstilbestrol and urethane. Genotoxic noncarcinogens are 8-hydroxyquinoline, emodin, acetonitrile and diallylphthalate, L-ascorbic acid. Nongenotoxic carcinogens are methyl carbamate, O-nitrotoluene, 1,4-dioxane, tetrachloroethylene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. And nongenotoxic noncarcinogens are D-mannitol, 1,2-dichlorobenzene, caprolactam, bisphenol A and chlorpheniramine maleate.

Keywords: genotoxicity; carcinogenicity; oxidative stress; hydrogen peroxide (H₂O₂)